Pentagastrin
Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test. Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. (In Vitro) :Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells. (In Vivo) :Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury.
Product Specifications
CAS Number
5534-95-2
Product Name Alternative
Pentagastrin | NCGC00183362-01 | Pentagastrinum | Peptavlon
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 34 mg/mL; 44.28 mM
Smiles
CSCC[C@H] (NC (=O) [C@H] (Cc1c[nH]c2ccccc12) NC (=O) CCNC (=O) OC (C) (C) C) C (=O) N[C@@H] (CC (O) =O) C (=O) N[C@@H] (Cc1ccccc1) C (N) =O
Molecular Formula
C37H49N7O9S
Molecular Weight
767.89
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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