CCRF-CEM SMAD/TGFbeta Reporter (Luc) stable cell line

CCRF-CEM SMAD/TGFbeta Reporter (Luc) cells are derived from the human CCRF-CEM T lymphoblast cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. CCRF-CEM cell line was generated from acute lymphoblastic leukemia, has been widely used for investigating the mechanisms underlying leukemia development, progression, and drug resistance. Additionally, these cells are often employed in screening assays to evaluate the efficacy and toxicity of potential anti-leukemic drugs. CCRF-CEM SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.