BIBB 515
BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S) -2, 3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.
Product Specifications
CAS Number
156635-05-1
Product Name Alternative
BIBB 515 | BIBB-515 | BIBB515
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 2.5 mg/mL (6.56 mM)
Smiles
Clc1ccc (cc1) C (=O) N1CCC (CC1) =Cc1ccc (cc1) C1=NCCO1
Molecular Formula
C22H21ClN2O2
Molecular Weight
380.87
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4-Chlorobenzoyl) -4- ((4- (2-oxazolin-2-yl) benzylidene) ) piperidine
Available Sizes
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