S217879

S217879 is a highly potent and selective NRF2 activator. S217879 disrupts the KEAP1-NRF2 interaction leading to robust NRF2 pathway activation. S217879 can be used for non-alcoholic steatohepatitis (NASH) research[1].

Product Specifications

CAS Number

2700303-28-0

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s217879.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C=C1[C@H](N2C3)C)[C@H](CC(O)=O)C4=CC=C5C(N=NN5CCOCCOC6=CC3=C(OS2(=O)=O)C=C6)=C4C

Molecular Formula

C30H32N4O7S

Molecular Weight

592.66

References & Citations

[1]Seedorf K, et al. Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice. JHEP Rep. 2022 Dec 16;5 (4) :100651.