P-MPPI hydrochloride

P-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.) ) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.) ) reduced the effect of 8-OH-DPAT on waking and REM sleep. Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture. No overt behavioural change was produced by p-MPPI alone. Thus, p-MPPI behaved as a true 5-HT (1A) antagonist.