MLS0315771
MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM) .MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 enhances mannose flux toward glycosylation. It ~50% of embryos appeared sick within 20 min at 8-10 μM, and most of them die by 30-60 min.
Product Specifications
CAS Number
727664-91-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (365.86 mM)
Smiles
Cc1ccc (C) c (c1) -n1sc2cc (F) ccc2c1=O
Molecular Formula
C15H12FNOS
Molecular Weight
273.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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