NBD-GPP
NBD-GPP is a fluorescent analog of geranyl pyrophosphate (GPP) . It serves as lipid donor for farnesyltransferase (FTase) -one of the three mammalian protein prenyltransferases. The attachment of the NBD-geranyl group to protein substrates allows for efficient fluorescence based FTase activity assays and inhibitor screening.
Product Specifications
Product Name Alternative
3,7-dimethyl-8- (7-nitro-benzo[1,2,5]oxadiazol-4-ylamino), -octa-2,6-diene-1-pyrophosphate, Fluorescent lipid donor for protein farnesyltransferase (FTase)
Concentration
1 mM
Purity
≥ 95% (HPLC)
Form
Liquid (Supplied as 1 mM solution in 25 mM (NH 4) 2CO3)
Smiles
C1 (ccc (c2c1non2) [N+] (=O) [O-]) NC/C (=C/CC/C (=C/COP (=O) (O) OP (=O) (O) O) /C) /C
Molecular Formula
C16H22N4O10P2
Molecular Weight
Theoretical MW: 492.31 g/mol
Storage Conditions
Store at -20 °C
Notes
For research use only.
Applications Notes
Spectroscopic Propertie: λexc 480 nm, λem 530 nm, ε 11.0 L mmol-1 cm-1 (pH 7.5) .
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