Aβ1–42 aggregation inhibitor 1
Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC50 value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM. Aβ1-42 aggregation inhibitor 1 has the potential for the research of anti-Alzheimer's disease[1].
Product Specifications
CAS Number
[2439107-75-0]
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aβ1-42-aggregation-inhibitor-1.html
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN1C2=CC=C(/C=C/C3=CC=C(C=C3)NC(NCCN4CCCC4)=S)C=C2C5=CC=CC=C51
Molecular Formula
C29H32N4S
Molecular Weight
468.66
References & Citations
[1]Dushyant V Patel, et al. Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents. Bioorg Chem. 2020 Aug;101:103977.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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