AP1867-3- (aminoethoxy)

AP1867-3- (aminoethoxy), the AP1867 based moiety, is a synthetic ligand for FKBP. AP1867-3- (aminoethoxy) can be used in the synthesis of PROTAC FKBP12 F36V degrader[1].

Product Specifications

CAS Number

[2127390-15-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

FKBP; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ap1867-3-methoxyethylamine.html

Purity

98.60

Solubility

DMSO : 240 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN)=C3)CCC4=CC=C(OC)C(OC)=C4

Molecular Formula

C38H50N2O9

Molecular Weight

678.81

Precautions

H302, H315, H319

References & Citations

[1]Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12 (10) :2570-2578.