Arpc2 (NM_029711) Mouse Recombinant Protein
Product Specifications
Background
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .[UniProtKB/Swiss-Prot Function]
Synonyms
34kDa; 2210023N03Rik; p34-Arc
Gene ID
76709
UniProt
Q9CVB6
Accession Number mRNA
NM_029711
Chromosomal Location
1 C3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
34.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Arpc2
Species
Mouse
Protein ID
NP_083987
Overview
Purified recombinant protein of Mouse actin related protein 2/3 complex, subunit 2 (Arpc2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/76709
Uniprot URL
https://www.uniprot.org/uniprot/Q9CVB6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_029711
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_083987
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