TS-011
TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
Product Specifications
CAS Number
339071-18-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ts-011.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C(/N=C/NO)C=C1)=C1N2CCOCC2
Molecular Formula
C11H14ClN3O2
Molecular Weight
255.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161 (6) :1391-402.|[2]Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul;27 (6) :1350-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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