(S, R, S) -AHPC-PEG2-NH2 (hydrochloride)

(S, R, S) -AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

Product Specifications

CAS Number

[2097973-72-1]

Product Name Alternative

VH032-PEG2-NH2 (hydrochloride) ; VHL Ligand-Linker Conjugates 3 (hydrochloride) ; E3 ligase Ligand-Linker Conjugates 6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_6.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 175 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl

Molecular Formula

C28H42ClN5O6S

Molecular Weight

612.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61 (2) :504-513.