ADRM1 Polyclonal Antibody

The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.

110 kDa cell membrane glycoprotein, adhesion regulating molecule 1, Adhesion-regulating molecule 1, ADRM 1, Adrm1, ADRM1, ARM 1, ARM-1, ARM1, Gp110, hRpn13, M (r) 110,000 surface antigen, Proteasomal ubiquitin receptor ADRM1, proteasome regulatory particle non ATPase 1