D-5-Hydroxytryptophan

D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3].

Product Specifications

CAS Number

[4350-07-6]

Product Name Alternative

D-5-HTP; 5-Hydroxy-D-tryptophan

UNSPSC

12352209

Hazard Statement

H301

Target

5-HT Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-5-hydroxytryptophan.html

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@H](N)CC1=CNC2=C1C=C(O)C=C2

Molecular Formula

C11H12N2O3

Molecular Weight

220.23

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16 (3) :419-22.|[2]Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31 (1) :39-46.|[3]Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60 (1) :129-32.