Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Human Synaptotagmin 1 DyLight® 488 conjugated SYT1 Antibody, Carrier-free

Selected Variant

A02314-Dyl488-carrier-free

Size: 100 µg

Boster Bio Anti-Human Synaptotagmin 1 DyLight® 488 conjugated SYT1 Antibody catalog # A02314-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Background

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse.

Synonyms

Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT1; SVP65; SYT

Gene Name

synaptotagmin 1

Gene ID

6857

UniProt

P21579

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Synaptotagmin 1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Label

DyLight®488

Tissue Specificity

Expressed in melanocytes (PubMed:23999003).

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca (2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca (2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Components

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

References & Citations

1. Fernandez-Chacon, R., Konigstorfer, A., Gerber, S. H., Garcia, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., Sudhof, T. C. Synaptotagmin I functions as a calcium regulator of release probability. Nature 410: 41-49, 2001. 2. Poskanzer, K. E., Marek, K. W., Sweeney, S. T., Davis, G. W. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature 426: 559-563, 2003.

Storage Conditions

At -20℃ for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

30392 MW

Observed Molecular Weight

39 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Flow Cytometry (Fixed), 1-3μg/1x10<sup>6</sup> cells

Subcellular Location

Cytoplasmic vesicle, secretory vesicle membrane.

Protein Name

Tumor necrosis factor receptor superfamily member 14

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-VPAC2/VIPR2 Antibody Picoband®, PE Conjugate
A03768-1-PE 100 µg/Vial

Anti-VPAC2/VIPR2 Antibody Picoband®, PE Conjugate

Sign In for Pricing
View Details
Caldesmon, HMW (h-Caldesmon) (h-CALD), CF647 conjugate, 0.1mg/mL
BNC470819-500 1x 500 µL

Caldesmon, HMW (h-Caldesmon) (h-CALD), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Noxa Recombinant Rabbit Monoclonal Antibody [JA30-03]
ET1704-35 100 µL

Noxa Recombinant Rabbit Monoclonal Antibody [JA30-03]

Sign In for Pricing
View Details
Anti-ERK2/MAPK1 Antibody Picoband®
PA1310-1 100 µg/Vial

Anti-ERK2/MAPK1 Antibody Picoband®

Sign In for Pricing
View Details
ACTH (Adrenocorticotrophic Hormone) (2F6), CF640R conjugate, 0.1mg/mL
BNC401014-100 1x 100 µL

ACTH (Adrenocorticotrophic Hormone) (2F6), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Cytokeratin 10 (LH2), CF594 conjugate, 0.1mg/mL
BNC940674-100 1x 100 µL

Cytokeratin 10 (LH2), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details