Noxa Recombinant Rabbit Monoclonal Antibody [JA30-03]
Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis) under a broad range of physiological conditions. Bcl-2, Bcl-xL, and several related proteins inhibit apoptosis, whereas other members of the Bcl-2 family, such as Bax and Bak, enhance cell death. NOXA, a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. Murine cells constitutively express NOXA mRNA in small amounts in various organs; X-ray irradiation increases NOXA mRNA and protein expression levels. In human cells, NOXA, alternatively designated PMA-induced protein 1 or APR, displays high expression in the adult T cell leukemia cell line IKD, where it may function as an immediate-early-response gene. The NOXA protein selectively localizes to mitochondria.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PMA-induced protein 1, PMAIP1, NOXA
Swiss Prot
Q13794 Human, Q9JM54 Mouse, Q5U777 Rat
Cellular Locus
Mitochondrion.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human Noxa aa 5-54 / 54.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Human spleen tissue, human liver tissue, Jurkat, mouse lung tissue, rat lung tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:8,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 6 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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