Anti-MICALL2 Antibody Picoband®, iFluor647 Conjugate

Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Sakane, A., Yano, T. A., Uchihashi, T., Horikawa, K., Hara, Y., Imoto, I., ... & Sasaki, T. (2021). JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes. Communications biology, 4(1), 551. 2. Zhu, L. Y., Zhang, W. M., Yang, X. M., Cui, L., Li, J., Zhang, Y. L., ... & Zhang, Z. G. (2015). Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal–epithelial transition. Cancer letters, 363(1), 71-82. 3. Min, P., Zhao, S., Liu, L., Zhang, Y., Ma, Y., Zhao, X., ... & Du, J. (2019). MICAL‐L2 potentiates Cdc42‐dependent EGFR stability and promotes gastric cancer cell migration. Journal of cellular and molecular medicine, 23(6), 4475-4488.

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Western blot, 0.25-0.5 μg/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human<br> Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>