M3-Huwentoxin IV

M3-HwTx-IV is a potent peptide inhibitor of voltage-gated sodium channels (NaV), with high affinity for hNaV1.7 (IC50 3.3 nM) and related subtypes. It is a valuable research tool for in vitro electrophysiology and for studying NaV1.7's role in pain signaling, as evidenced by its dose-dependent alleviation of spontaneous pain in rodent models.