JHU37160
JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue[1].
Product Specifications
CAS Number
[2369979-68-8]
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jhu37160.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=C2NC3=CC=C(Cl)C=C3N=C(N4CCN(CC)CC4)C2=CC=C1
Molecular Formula
C19H20ClFN4
Molecular Weight
358.84
References & Citations
[1]Bonaventura J, et, al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11;10 (1) :4627.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR3; mAChR4
Available Sizes
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SPTLC1 (Serine Palmitoyltransferase, Long Chain Base Subunit 1, HSAN, HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI, Hereditary Sensory Neuropathy, Type 1, Long chain base biosynthesis protein 1, Serine-palmitoyl-CoA transferase 1)
