Saruparib
Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair[1][2].
Product Specifications
CAS Number
2589531-76-8
Product Name Alternative
AZD5305
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/saruparib.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC=C(N2CCN(CC3=CC(N4)=C(N=C3)C=C(CC)C4=O)CC2)C=C1)NC
Molecular Formula
C22H26N6O2
Molecular Weight
406.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Illuzzi G, et, al. Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clin Cancer Res. 2022 Nov 1;28 (21) :4724-4736.|[2]Johannes JW, et, al. Discovery of 5-{4-[ (7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl) methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305) : A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. J Med Chem. 2021 Oct 14;64 (19) :14498-14512.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PARP1; PARP2
Available Sizes
Frequently Asked Questions
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