Anti-Bcl-2 Monoclonal Antibody
Boster Bio Anti-Bcl-2 Monoclonal Antibody catalog # M00040-3. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Apoptosis regulator Bcl-2; BCL2;
Gene Name
BCL2
UniProt
P10415
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic Peptide of Bcl-2
Clonality
Monoclonal
Clone
Clone: 6B5
Tissue Specificity
Expressed in a variety of tissues.
Applications
IHC, WB
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .
Molecular Weight
26266 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Apoptosis regulator Bcl-2
Subcellular Location
Mitochondrion outer membrane
Protein Name
Apoptosis regulator Bcl-2
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