Anti-Mitofusin-2 MFN2 Antibody

Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2) . MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4) . Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5) .

MFN2 antibody is human, mouse and rat reactive. At least three isoforms of MFN2 are known to exist. MFN2 antibody is predicted to not cross-react with MFN1.

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303) . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303) . Overexpression induces the formation of mitochondrial networks (PubMed:28114303) . Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable) . Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity) . Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity) . Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051) . Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051) . Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity) . Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity) .