Human EDNRB Full Length Protein (VLP)
Human EDNRB Full Length Protein-VLP (EDB-H52P7) is expressed from human 293 cells (HEK293) . It contains AA Glu 27 - Ser 442 (Accession # P24530-1) .
Product Specifications
Background
Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR) . Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.
Specifications
This protein .
Accession Number
P24530-1
Expression Region
Glu 27 - Ser 442
Host
HEK293
Target
EDNRB
Conjugation
Unconjugated
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 12 months under sterile conditions.
Endotoxin
1.0 EU per μg
Bioactivity
Immobilized Human EDNRB Full Length Protein-VLP (Cat. No. EDB-H52P7) at 5 μg/mL (100 μL/well) can bind Anti-EDNRB Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).
Format
Liquid
Buffer
PBS, Arginine, pH7.4
Additives
Trehalose
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/EDB-H52P7.pdf
Species
Human
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