Anti-GLIPR1 Antibody

The glioma pathogensis-related protein 1 (GLIPR1) is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1) . GLIPR1 is a tumor suppressor whose expression is regulated by p53; its increased expression is associated with myelomocytic differentiation in macrophages, whereas decreased expression of this gene through gene methylation is associated with prostate cancer (2) . The GLIPR1 gene is part of a p53 target gene cluster that includes GLIPR1L1 and GLIPR1L2, two highly homologous proteins whose expression patterns vary (3) .

GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.

GLIPR1 antibody was raised against an 18 amino acid peptide near the center of human GLIPR1. The immunogen is located within amino acids 60 - 110 of GLIPR1.

According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.