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RS 09 (TFA)

RS 09 TFA is an LPS (HY-D1056) peptide mimic and TLR4 agonist. RS 09 TFA can bind to TLR-4 and activate NF-κB. RS 09 TFA can function as an adjuvant in vivo, enhancing the antigen-specific immune response[1].

Product Specifications

UNSPSC

12352209

Target

NF-κB; Toll-like Receptor (TLR)

Type

Peptides

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rs-09-tfa.html

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL

Smiles

OC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](N)C)=O)=O)=O)CC3=CNC=N3)=O)C)=O)CC(C)C)=O)CO)=O.O=C(O)C(F)(F)F

Molecular Formula

C33H50F3N9O11

Molecular Weight

805.80

References & Citations

[1]Arulkumaran Shanmugam, et al. Synthetic Toll Like receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants. PLoS One. 2012;7 (2) :e30839.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

TLR4

Citation 01

Clin Exp Hypertens. 2025 Dec;47 (1) :2486829.|Int Immunopharmacol. 2024 May 9:134:112188.|J Adv Res. 2024 Nov 14:S2090-1232 (24) 00536-8.|Phytomedicine. 2022 Oct:105:154360.|Placenta. 2025 Jan 3:160:89-99.|ACS Chem Neurosci. 2025 Mar 5;16 (5) :968-980.|Bioact Mater. 2022 Nov 9:23:69-79.|Biochim Biophys Acta Mol Basis Dis. 2025 Feb 8;1871 (3) :167710.|Cell Signal. 2025 Sep 18:136:112140.|Hepatology. 2025 Nov 7.|J Ethnopharmacol. 2025 Oct 15;355 (Pt B) :120749.|Mol Cell Biol. 2025 Nov 25:1-12.|Mol Neurobiol. 2025 May;62 (5) :6070-6087.|Neurochem Int. 2025 Feb 4:105940.|NPJ Parkinsons Dis. 2025 Nov 28;11 (1) :342.|Phytomedicine. 2024 Dec 3:136:156314.

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