ZC0101
Product Specifications
UNSPSC Description
ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].
Target Antigen
Apoptosis; Indoleamine 2,3-Dioxygenase (IDO); Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zc0101.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CCCN1C(/C=C/C2=CC=CC=C2C3=CNC=N3)=O
Molecular Weight
293.32
References & Citations
[1]Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147772/ZC0101-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147772/
Clinical Information
No Development Reported
CAS Number
2541604-52-6
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