PL-017

This compound is a potent and selective μ opioid receptor agonist, with an IC50 of 5.5 nM at μ sites and >10,000 nM at δ sites. In vivo, it induces analgesia, catalepsy, and hyperthermia in rats via central administration, effects which are reversible by naloxone. It is a valuable research tool for studying μ-opioid receptor pharmacology and neurobiology in both in vitro binding assays and in vivo behavioral models.