Recombinant Human IL-12 p40 protein(His Tag)

Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.

IL-12/IL-23 p, IL-12 subunit p, NK cell stimulatory factor chain, NK cell Stimulating Factor Chain, CLMF p, IMD, IL12B, CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40), IL-12/IL-23 p40, NK cell Stimulating Factor Chain 2, p40, Interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, IL 12B, IL12 p40, Interleukin 12 beta chain, Interleukin 12 p40

Measure by its ability to induce cell proliferation in PHA-activated human peripheral blood lymphocytes (PBMC) using a concentration range of 5-50 ng/mL. Note: Results may vary from different PBMC donors.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.