Phospho-Akt(Ser473) antibody
Product Specifications
Background
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. This antibody detects all the members of AKT with phospho-modification.
Synonyms
RAC-alpha serine/threonine-protein kinase|Protein kinase B (PKB)|Protein kinase B alpha (PKB alpha)|Proto-oncogene c-Akt|RAC-PK-alpha|AKT1|PKB|RAC
UniProt
P31749
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
v-akt murine thymoma viral oncogene homolog 1
Target
Phospho-Akt(Ser473)
Clonality
Monoclonal
Isotype
IgG1
Clone
5H4
Applications
ELISA, IHC, WB
Field of Research
Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:4000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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