Recombinant Human ST8SIA1 Protein (His Tag)
Product Specifications
Background
Α-N-Acetylneuraminide α-2,8-Sialyltransferase (ST8SIA1) belongs to the glycosyltransferase 29 family. ST8SIA1 is a sialytransferase that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce GD3 and GT3. ST8SIA1 is highly expressed in melanoma cell lines, adult and fetal brain, low expressed in adult and fetal lung. ST8SIA1 may act as a type II transmembrane protein with a short N-termianl cytoplasmic domain and a single-pass transmembrane domain folowed by an enzymatic domain in the lument of the Golgi apparatus.
Abbreviation
ST8SIA1
Synonyms
8-Sialyltransferase;8-Sialyltransferase 8A; Alpha-2; Alpha-N-Acetylneuraminide Alpha-2; Ganglioside GD3 Synthase; Ganglioside GT3 Synthase; SIAT8; SIAT8-A; SIAT8A; ST8SIA1; ST8SiaI; Sialyltransferase 8A; Sialytransferase St8Sia I
UniProt
Q92185
Accession Number
Q92185
Expression System
HEK293 Cells
Tag
C-His
Sequence
Tyr49-Ser356
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
36.2 kDa
Observed Molecular Weight
48 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Species
Human
Available Sizes
Documents
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