pan Cytokeratin Recombinant Mouse Monoclonal Antibody [PD00-15]
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. For example, cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium. Recognizes human cytokeratins 4, 5, 6, 8, 10, 13, and 18.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
pan ck antibody pan-ck antibody panck antibody
Abbreviation
pan Cytokeratin
Swiss Prot
Q01546 Human, Q7Z794 Human
Cellular Locus
Cytoplasm.
Host
Mouse
Species Reactivity
Human
Immunogen
Recognizes human cytokeratins 4, 5, 6, 8, 10, 13, and 18.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Recombinant Mouse monoclonal Antibody
Applications
IHC-P, IF-Cell, FC, mIHC
Positive Control
Human skin tissue, human breast tissue, human small intestine tissue, MCF-7, human pancreatic carcinoma.
Concentration
1 mg/mL
Dilution
IHC-P: 1:500-1:1,000 ;IF-Cell: 1:50 ;FC: 1:500-1:1,000 ;mIHC: 1:3,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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