Recombinant Human OSMR/IL31RB Protein (aa 28-739, His Tag)

Product Specifications

Background

Oncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.

Abbreviation

OSMR; IL31RB

Synonyms

PLCA; OSMR; IL-31R-beta; IL-31RB; OSMRB; PLCA1; IL-31 Receptor Subunit Beta; IL-31R Subunit Beta; Interleukin-31 Receptor Subunit Beta; Oncostatin-M specific receptor subunit beta; Oncostatin-M-Specific Receptor Subunit Beta

UniProt

Q99650

Accession Number

Q99650

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu28-Ser739

Field of Research

Signal Transduction; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.