GCNT3 Rabbit Polyclonal Antibody

This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009], catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3- (N-acetyl-beta-D-glucosaminyl-1,6) -N-acetyl-D-galactosaminyl-R., catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R., function:Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development., induction:By all-trans retinoic acid (ATRA), TNF-alpha and IL13. Strongly down-regulated in colorectal cancer., online information:Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase, online information:GlycoGene database, pathway:Protein modification; protein glycosylation., PTM:N-glycosylated., similarity:Belongs to the glycosyltransferase 14 family., tissue specificity:Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.

GCNT3; Beta-1; 3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; C2GnT-mucin type; C2GnT-M; hC2GnT-M; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; C2/4GnT