ELOC Polyclonal Antibody

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Elongin C; Transcription Elongation Factor B (SIII) ; Polypeptide 1 (15kDa; Elongin C) ; RNA Polymerase II Transcription Factor SIII Subunit C; Transcription Elongation Factor B Polypeptide 1; Transcription Elongation Factor B Subunit 1; Elongin 15 KDa Subunit; SIII P15.