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TGFBI Polyclonal Antibody

Product Specifications

Background

TGFBI, also named as BIGH3, Kerato-epithelin and RGD-CAP, binds to type I, II, and IV collagens. TGFBI is an adhesion protein which may play an important role in cell-collagen interactions. In cartilage, it may be involved in endochondral bone formation. TGFBI is an extracellular matrix adaptor protein, it has been reported to be differentially expressed in transformed tissues. TGFBI is a predictive factor of the response to chemotherapy, and suggest the use of TGFBI-derived peptides as possible therapeutic adjuvants for the enhancement of responses to chemotherapy. Defects in TGFBI are the cause of epithelial basement membrane corneal dystrophy (EBMD) . Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1) . Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1) . Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB) . Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB) . Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A) . Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD) .

Abbreviation

TGFBI

UniProt

Q15582

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Fusion protein of human TGFBI

Target

>RGD containing collagen associated protein; AI181842; AI747162; Beta ig; Beta ig h3; Beta ig-h3; BGH3; Big h3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato epithelin; Kerato-epithelin; LCD1; MGC150270; RGD CAP; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; TGFBI transforming growth factor; beta induced;68kDa; Transforming growth factor beta induced protein ig h3; Transforming growth factor-beta-induced protein ig-h3

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Developmental Biology; Neuroscience; Signal Transduction

Purification

Antigen affinity purification

Concentration

1.02 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

75 kDa

Observed Molecular Weight

Refer to figures

Citation 01

https://pubs.rsc.org/en/content/articlehtml/2020/fo/c9fo02521a

Isotype

IgG

Available Sizes

Curated Selection

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