Recombinant Murine Eotaxin/CCL11 (rMuEotaxin/CCL11)
Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.
Product Specifications
Source
Escherichia coli.
Field of Research
Immunology & Inflammation
Endotoxin
Less than 1EU/μg of rMuEotaxin/CCL11 as determined by LAL method.
Purity
>95% by SDS-PAGE and HPLC analyses.
Bioactivity
Measured by its ability to chemoattract mouse CCR3 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 1-5 ng/mL.
Form
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Molecular Weight
Approximately 8.3 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
Storage Conditions
Notes
For research use only.
Applications Notes
Preservative
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
AA Sequence
HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP
Available Sizes
Frequently Asked Questions
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