Anti-Neuralized-1 (V250) NEURL1 Antibody

Boster Bio Anti-Neuralized-1 (V250) NEURL1 Antibody catalog # A11177. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

E3 ubiquitin-protein ligase NEURL1;2.3.2.27; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67; RING-type E3 ubiquitin transferase NEURL1 ; NEURL1; NEURL, NEURL1A, RNF67;

Gene Name

NEURL1

UniProt

O76050

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 221-270 of Human Neuralized-1.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

IHC: 1:50-1:200

Form

Liquid

Function

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.