Naloxonazine

Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1].

Product Specifications

CAS Number

[82824-01-9]

UNSPSC

12352005

Target

Opioid Receptor; Parasite

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/naloxonazine.html

Solubility

10 mM in DMSO

Smiles

O[C@@]1(CC/2)[C@@]([C@](O3)([H])C2=N\N=C(CC4)\[C@@](OC5=C6O)([H])[C@]7(CCN8CC=C)C5=C(C=C6)C[C@]8([H])[C@@]74O)(CC9)C(C3=C%10O)=C(C=C%10)C[C@@]1([H])N9CC=C

Molecular Formula

C38H42N4O6

Molecular Weight

650.76

References & Citations

[1]Géraldine De Muylder, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10 (12) :e0005234. |[2]Roberto Ciccocioppo, et al. Effect of selective blockade of mu (1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology. 2002 Sep;27 (3) :391-9.