Naloxonazine
Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1].
Product Specifications
CAS Number
[82824-01-9]
UNSPSC
12352005
Target
Opioid Receptor; Parasite
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/naloxonazine.html
Solubility
10 mM in DMSO
Smiles
O[C@@]1(CC/2)[C@@]([C@](O3)([H])C2=N\N=C(CC4)\[C@@](OC5=C6O)([H])[C@]7(CCN8CC=C)C5=C(C=C6)C[C@]8([H])[C@@]74O)(CC9)C(C3=C%10O)=C(C=C%10)C[C@@]1([H])N9CC=C
Molecular Formula
C38H42N4O6
Molecular Weight
650.76
References & Citations
[1]Géraldine De Muylder, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10 (12) :e0005234. |[2]Roberto Ciccocioppo, et al. Effect of selective blockade of mu (1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology. 2002 Sep;27 (3) :391-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
Curated Selection
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