Anti-Integrator complex subunit 6 INTS6 Antibody
Boster Bio Anti-Integrator complex subunit 6 INTS6 Antibody catalog # A07753. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Integrator complex subunit 6; Int6; DBI-1; Protein DDX26; Protein deleted in cancer 1; DICE1; INTS6; DBI1, DDX26, DDX26A;
Gene Name
INTS6
UniProt
Q9UL03
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human INTS6 (NP_036273.1) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable) . Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267) . May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144) .
Molecular Weight
100390 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Integrator complex subunit 6
Subcellular Location
Nucleus
Protein Name
Integrator complex subunit 6
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