Anti-ZBTB33 Antibody
Boster Bio Anti-ZBTB33 Antibody catalog # A04754. Tested in WB, ChIP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Transcriptional regulator Kaiso; Zinc finger and BTB domain-containing protein 33; ZBTB33; KAISO, ZNF348;
Gene Name
ZBTB33
UniProt
Q86T24
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human Kaiso/Kaiso/ZBTB33 (NP_006768.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in vascular endothelium.
Applications
WB, ChIP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS) . Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453) .
Molecular Weight
74484 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Transcriptional regulator Kaiso
Subcellular Location
Nucleus
Protein Name
Transcriptional regulator Kaiso
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