Anti-Tribbles homolog 1 TRIB1 Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596) . The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797) . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596) . Binds selectively the recognition sequence of CEBPA (PubMed:26455797) . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1- dependent manner (By similarity) . Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity) . Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797) .