Anti-LINGO1 Antibody
Boster Bio Anti-LINGO1 Antibody catalog # A02497. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A; LINGO1; LERN1, LRRN6A; UNQ201/PRO227;
Gene Name
LINGO1
UniProt
Q96FE5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human LINGO1
Clonality
Polyclonal
Tissue Specificity
Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321) . Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088) . Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity) .
Molecular Weight
69876 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A02497
Product MSDS
https://www.bosterbio.com/msds?sku=A02497
Other Gene Names
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Subcellular Location
Cell membrane
Protein Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
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