Anti-Myotubularin (Y290) MTM1 Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI (3,5) P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414) . Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070) . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508) . Plays a role in mitochondrial morphology and positioning (PubMed:21135508) . Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508) . In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870) .