EGR-1-IN-1

EGR-1-IN-1 (IT25) is an inhibitor targeting EGR-1, with IC50 of 1.86 μM. EGR-1-IN-1 can be used in the research of inflammatory skin diseases[1].

Product Specifications

UNSPSC

12352005

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/egr-1-in-1.html

Purity

98.11

Solubility

DMF : 1.25 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

COC1=CC2=C(/C(C(N2)=O)=N/NC(NC3=CC=C(C=C3)C#N)=S)C=C1

Molecular Formula

C17H13N5O2S

Molecular Weight

351.38

References & Citations

[1]Ahn S, et al. Design, synthesis, and biological evaluation of 2- (2-oxoindolin-3-ylidene) hydrazinecarbothioamides as a potential EGR-1 inhibitor for targeted therapy of atopic dermatitis. Bioorg Chem. 2024 Jul;148:107481.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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