NQ301
NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC50 of 10 mg/mL.
Product Specifications
CAS Number
[130089-98-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H372, H400
Target
Thrombin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/NQ301.html
Purity
98.98
Solubility
DMSO : ≥ 7.14 mg/mL
Smiles
O=C1C(NC2=CC=C(C(C)=O)C=C2)=C(Cl)C(C3=C1C=CC=C3)=O
Molecular Formula
C18H12ClNO3
Molecular Weight
325.75
Precautions
H315, H319, H335, H372, H400
References & Citations
[1]Jin YR, et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. Basic Clin Pharmacol Toxicol. 2005 Sep;97 (3) :162-7.|[2]Zhang YH, et al. Antiplatelet effect of 2-chloro-3- (4-acetophenyl) -amino-1,4-naphthoquinone (NQ301) : a possible mechanism through inhibition of intracellular Ca2+ mobilization. Biol Pharm Bull. 2001 Jun;24 (6) :618-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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