GNF-2-deg

GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC50 of 0.83 μM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC90 of 3.5 μM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC90 of 1.96-7.79 μM. (Pink: ligand for target protein (HY-161805) ; Black: linker (HY-42149) ; Blue: ligand for E3 ligase (HY-23095) ) [1]

Product Specifications

UNSPSC

12352005

Target

Dengue Virus; PROTACs

Type

Reference compound

Related Pathways

Anti-infection; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gnf-2-deg.html

Smiles

O=C(NCCOCCOCCOC1=CC=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=C1)C4=CC=CC(C5=CC(NC6=CC=C(OC(F)(F)F)C=C6)=NC=N5)=C4

Molecular Formula

C37H33F3N6O9

Molecular Weight

762.69

References & Citations

[1]Liu HY, et al., Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nat Commun. 2024 Jun 19;15 (1) :5179.