VU0453379
VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].
Product Specifications
CAS Number
1638646-27-1
Product Name Alternative
AM152 (sodium),AZD-3355 (napadisylate)
UNSPSC
12352005
Target
GCGR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/vu0453379.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC[C@H]1N(CCC1)C(C)C)C(C2=C3N(C4=C2C=CC=C4)C)=CN(C3=O)C5CCCC5
Molecular Formula
C26H34N4O2
Molecular Weight
434.57
References & Citations
[1]Morris LC, et al. Discovery of (S) -2-cyclopentyl-N- ((1-isopropylpyrrolidin2-yl) -9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM) . J Med Chem. 2014 Dec 11;57 (23) :10192-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY424942 100 µg
Complement factor 8 beta (C8B) (NM_000066) Human Over-expression Lysate
Sign In for Pricing
View Details 
