2-Phenyl-2- (1-piperidinyl) propane

2-Phenyl-2- (1-piperidinyl) propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2- (1-piperidinyl) propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM) [1].

Product Specifications

CAS Number

[92321-29-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-phenyl-2-1-piperidinyl-propane.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(N1CCCCC1)(C2=CC=CC=C2)C

Molecular Formula

C14H21N

Molecular Weight

203.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Walsky RL, et al. A comparison of 2-phenyl-2- (1-piperidinyl) propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos. 2007 Nov;35 (11) :2053-9.