SR1078
SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ) . SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription[1][2].
Product Specifications
CAS Number
1246525-60-9
UNSPSC
12352005
Hazard Statement
H302
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SR1078.html
Purity
99.75
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C1)C2=CC=C(C(F)(F)F)C=C2
Molecular Formula
C17H10F9NO2
Molecular Weight
431.25
Precautions
H302
References & Citations
[1]Wang Y, et al. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol. 2010 Nov 19;5 (11) :1029-34.|[2]Wang Y, Billon C, Walker JK, Burris TP. Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism. ACS Chem Neurosci. 2016;7 (2) :143-148.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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