xCT/SLC7A11 Mouse Monoclonal Antibody [A7C6]
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
SLC7A11
Swiss Prot
Q9UPY5 Human, Q9WTR6 Mouse
Cellular Locus
Cell membrane, Cell projection, microvillus membrane.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
293 cell line overexpressing SLC7A11.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
HT-29 cell lysates, HeLa, A549, HT-29, human colon tissue, human pancreas tissue.
Concentration
2 mg/mL
Dilution
WB: 1:500 ;IF-Cell: 1:100-1:250 ;IHC-P: 1:200-1:600 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 55 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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