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xCT/SLC7A11 Mouse Monoclonal Antibody [A7C6]

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Product Specifications

Product Name Alternative

Amino acid transport system xc xCT antibody antibody Amino acid transport system xc- antibody Calcium channel blocker resistance protein CCBR1 antibody Calcium channel blocker resistance protein CCBR1 antibody antibody CCBR1 antibody Cysteine/glutamate transporter antibody antibody Cystine/glutamate transporter antibody OTTHUMP00000164578 antibody SLC7A11 antibody Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody solute carrier family 7 antibody Solute carrier family 7 member 11 antibody Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody SYSTEM Xc (-) TRANSPORTER-RELATED PROTEIN antibody xCT antibody XCT_HUMAN antibody

Abbreviation

SLC7A11

Swiss Prot

Q9UPY5 Human, Q9WTR6 Mouse

Cellular Locus

Cell membrane, Cell projection, microvillus membrane.

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

293 cell line overexpressing SLC7A11.

Isotype

IgG2b

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

HT-29 cell lysates, HeLa, A549, HT-29, human colon tissue, human pancreas tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500 ;IF-Cell: 1:100-1:250 ;IHC-P: 1:200-1:600 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 55 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No

CAS Number

9007-83-4

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